| Pair Name | Pristimerin, Sorafenib | ||
| Phytochemical Name | Pristimerin (PubChem CID: 159516 ) | ||
| Anticancer drug Name | Sorafenib (PubChem CID: 216239 ) | ||
| Structure of Phytochemical |
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| Structure of Anticancer Drug |
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| Pair Name | Pristimerin, Sorafenib | |||
| Disease Info | [ICD-11: 2C12] | Hepatocellular carcinoma | Investigative | |
| Biological Phenomena | Inhibition-->Cell migration and angiogenesis | |||
| Gene Regulation | Up-regulation | Expression | CYCS | hsa54205 |
| Up-regulation | Cleavage | CASP3 | hsa836 | |
| Up-regulation | Cleavage | CASP4 | hsa837 | |
| Up-regulation | Expression | BAX | hsa581 | |
| Down-regulation | Expression | BCL2 | hsa596 | |
| Up-regulation | Expression | HSPA5 | hsa3309 | |
| Up-regulation | Expression | DDIT3 | hsa1649 | |
| Up-regulation | Phosphorylation | EIF2AK3 | hsa9451 | |
| Up-regulation | Phosphorylation | EIF2S1 | hsa1965 | |
| Down-regulation | Phosphorylation | AKT1 | hsa207 | |
| Up-regulation | Expression | FOXO1 | hsa2308 | |
| Up-regulation | Expression | PSMD9 | hsa5715 | |
| In Vitro Model | CRHCs | CRHCs isolated from the 9 patients would be used for the following experiments. | Homo sapiens (Human) | N.A. |
| Result | Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway | |||
| No. | Title | Href |
|---|---|---|
| 1 | Pristimerin synergistically sensitizes conditionally reprogrammed patient derived-primary hepatocellular carcinoma cells to sorafenib through endoplasmic reticulum stress and ROS generation by modulating Akt/FoxO1/p27kip1 signaling pathway. Phytomedicine. 2021 Jun;86:153563. doi: 10.1016/j.phymed.2021.153563. | Click |
